| Title |
Special Edition : Symposium on Nano and Biomaterials ; Alloy Design and Biocompatibility Evaluation of Low Modulus Titanium Alloys |
| Authors |
김승언(Seung Eon Kim); 정희원(Hi Won Jeong); 현용택(Yong Taek Hyun); 이동근(Dong Keun Lee); 이용태(Yong Tai Lee); 박중근(Joong Keun Park); 이준희(Jun Hee Lee) |
| ISSN |
1738-8228(ISSN), 2288-8241(eISSN) |
| Keywords |
Low modulus; Titanium; Electron theory; Anodic polarization; MG63 cell culture |
| Abstract |
Alloy design and in-vitro assessment of biocompatibilities of novel titanium alloys with low elastic modulus were studied. A contour map of elastic modulus which enables to predict low modulus alloy composition was established by using electron theory. Ti-30Ta-10Nb-10Zr, Ti-40Ta-10Nb-10Zr and Ti-40Ta10Nb-4Sn alloys were designed by using the contour map of elastic modulus, and Young`s moduli of those alloys were as low as around 60 GPa. Anodic polarization curves for the alloys represented that corrosion resistance of Ti-40Ta-10Nb-10Zr and Ti-40Ta-10Nb-10Zr was comparable to those of biomedically approved CP Ti and Ti-6Al-4V in simulated body fluid(Hank`s solution) at 37℃, while corrosion resistance of Ti-40Ta-10Nb-4Sn was inferior to those of CP Ti and Ti-6Al-4V. MTT assay with osteoblast-like cells(MG63) showed that the extent of initial cell attachment was similar in all alloys, while cell proliferation of Ti-40Ta-l0Nb10Zr and Ti-40Ta-10Nb-4Sn alloys was more sluggish than those in CP Ti and Ti-6Al-4V. It was therefore realized that the selection of alloying elements for designing low modulus alloys should be considered in the viewpoint of cell growth as well as cytotoxicity. |